Cyclobenzaprine Memorial Sloan Kettering Cancer Center
You may report side effects to FDA at FDA-1088 or at /medwatch. Although rare, an overdose involving Flexeril can occur and is usually the result of the aforementioned potentially critical overdose effects. If you or someone you know is experiencing overdose symptoms related to Flexeril and/or other substances, seek professional medical help by visiting an emergency room or contact 911 immediately. Cyclobenzaprine is available as immediate- and extended-release tablets and capsules. Flexeril is typically used in conjunction with physical therapy or exercise and other forms of treatment for applicable conditions.
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It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Cyclobenzaprine is used short-term to treat muscle spasms.
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It can lead to cardiac arrest, a dangerous drop in blood pressure, or seizures. Less common issues include central nervous depression. One of the more common effects of the Flexeril high is drowsiness. The dangers of taking more than prescribed are much greater than the reward of abusing it. Cyclobenzaprine can increase the effects of CNS depressants, such as alcohol, opioids, allergy medications, and sleeping pills.
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Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor.
Although it is an unscheduled drug with a relatively low potential for abuse, people can develop compulsive patterns of use with cyclobenzaprine, which can lead to serious consequences. According to the National Institute on Drug Abuse flexeril vs robaxin or NIDA, more than 50 million Americans aged 12 and over have reportedly misused a prescription drug at least once in their life. There were 25.2 million prescriptions wrote in 2011 that included cyclobenzaprine such as Flexeril.
Before taking cyclobenzaprine,
Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Flexeril. It is unknown if Flexeril passes into breast milk or if it could harm a nursing baby. Avoid driving or hazardous activity until you know how this medicine will affect you. Cyclobenzaprine is usually taken taken for up to 2 or 3 weeks.
- Follow all directions on your prescription label and read all medication guides or instruction sheets.
- It is unknown if this medication passes into breast milk.
- If signs of toxicity occur at any time during this period, extended monitoring is required.
- You also get to gain insight into what caused it to occur for you in the first place.
Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day.
All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. Our Flexeril (cyclobenzaprine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
It has a half-life of 18 hours so it will stay in the body for about 90 hours. This means it will show up on drug tests for nearly 4 days. If a person has liver or kidney problems, the drug may remain in the body for longer. This is because the liver will take longer to process the drug through. It’s important that someone on Flexeril let the test administrator know they’re taking Flexeril. This is because it can give false positives on other narcotic substances.
Flexeril is one of the most researched muscle relaxants, so there is more evidence to support its efficacy. Signs of overdose include chest pain, hallucinations, vomiting, rapid heartbeat, slurred speech, difficulty breathing, and extreme drowsiness. The risk of overdose is significantly increased when Flexeril is combined with other drugs, particularly alcohol or Benzodiazepines. This combination can cause extreme drowsiness and respiratory depression, but many people that abuse Flexeril will mix the substances anyway simply to increase the intoxication experienced.